The Economist offers some great advice to the McCain campaign

I think that the campaign may be too maverick-y to synthesize the recommendations:

First, Mr McCain should point out that his opponent is one of the least business-friendly Democratic candidates in a generation.

Second, Mr McCain should hammer away at the dangers of single-party rule in Washington, DC.

Third, Mr McCain should point out that his opponent has never once in his career said boo to a Democratic goose.